SnapShot: Chromatin Remodeling: INO80 and SWR1

SnapShot: Chromatin Remodeling: INO80 and SWR1

The INO80 and SWR1 complexes belong to the INO80 subfamily of ATP-dependent chromatin-remodeling complexes. These complexes interact with nucleosomes and remodel chromatin by either sliding nucleosomes along the DNA or exchanging histones within nucleosomes. In doing so, the INO80 and SWR1 complexes promote recruitment of regulatory factors to DNA. Distinct from other subfamilies of chromatin-r...

Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.

INO80 and SWR1 are two closely related ATP-dependent chromatin remodeling complexes that share several subunits. Ino80 was reported to be recruited to the HO endonuclease-induced double-strand break (DSB) at the budding yeast mating-type locus, MAT. We find Swr1 similarly recruited in a manner dependent on the phosphorylation of H2A (gammaH2AX). This is not unique to cleavage at MAT; both Swr1 ...

SnapShot: Chromatin Remodeling Complexes

Unique subunits Swp82, Taf14, Snf6, Snf11 Rsc3,5,7,9, 10,30, Htl1, Ldb7, and Rtt102 INO80 regulates transcription and is involved in DNA repair and cellcycle checkpoint adaptation. It has ATP-dependent nucleosome mobilization activity in vitro. SWR1 regulates transcription and is also involved in deposition of histone H2AZ, chromosome stability, and cell-cycle checkpoint adaptation. In vitro it...

SnapShot: Chromatin Remodeling: CHD

SnapShot: Chromatin Remodeling: ISWI